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Effects of stem cell transplantation on bone mineral density and vitamin D status in children with thalassemia major
Author(s) -
Gürlek Gökçebay Dilek,
Ozbek Namik,
Yazal Erdem Arzu,
Culha Vildan,
Yarali Nese,
Isik Pamir,
Avci Zekai,
Azik Fatih,
Demirel Fatma,
Tunc Bahattin
Publication year - 2017
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12876
Subject(s) - medicine , bone mineral , thalassemia , vitamin d and neurology , pediatrics , hematopoietic stem cell transplantation , transplantation , surgery , osteoporosis
HSCT is a curative treatment in TM , but conditioning and immunosuppressive treatment may affect bone metabolism. In this retrospective study, we aimed to compare BMD , vitamin D status, and growth in children with TM who underwent HSCT to those in children with TD TM . Twenty‐three children with TM who underwent HSCT (mean age 7.1 years [1.03‐14.7]) and 24 children with TD thalassemia (mean age 9.8 years [1.6‐14]) were recruited. Lumbar spine BMD of TD thalassemia patients was higher than those in patients who had HSCT at both baseline and second‐year assessments ( P =.009, P <.001, respectively). However, BMD Z scores or serum 25‐ OH vitamin D levels were not different in two groups. Being >10 years of age was a significant risk factor for low BMD , height, and weight Z score for both groups. Patients who underwent HSCT with Pesaro risk class II or III had higher risk for low BMD compared to those risk class I patients ( P =.044). In conclusion, children with TM who were >10 years at HSCT are at risk for low BMD and growth retardation. HSCT had no effect on BMD deficit in children with TM .