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Early and late neurological complications of liver transplantation in pediatric patients
Author(s) -
Gungor Serdal,
Kilic Betul,
Arslan Mujgan,
Selimoglu M. Ayse,
Karabiber Hamza,
Yilmaz Sezai
Publication year - 2017
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12872
Subject(s) - medicine , liver transplantation , incidence (geometry) , encephalopathy , headaches , etiology , pediatrics , ataxia , transplantation , retrospective cohort study , hepatic encephalopathy , surgery , cirrhosis , physics , psychiatry , optics
NCs occur commonly after solid organ transplantation and affect 15%‐30% of liver transplant recipients. The aim of this retrospective study was to evaluate the type and incidence of neurologic events in pediatric patients following LT . Between May 2006 and June 2015, 242 patients (118 females, 124 males) requiring LT for different etiologies at the İnönü University Liver Transplantation Institute were included. The incidence, types, and risk factors of NC s that occurred following LT were evaluated retrospectively. Neurologic events occurred in 57 (23.5%) of the patients. Early NC s were encephalopathy (12.4%), seizures (11.5%), and PRES (7%). Of 57 patients, five (8.7%) experienced NC s at least 1 month after LT ; these late NC s included tremor, headaches, encephalopathy, ataxia, and neuropathy. The psychiatric symptoms after LT were noted in 42 patients (17.4%). The mortality rate after LT in those with or without neurological events was not significantly different ( P =.73). There was a high incidence of serious neurologic events after LT . The major neurologic manifestation in our patients was encephalopathy followed by seizures.