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Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients
Author(s) -
Elhoff Justin J.,
Chowdhury Shahryar M.,
Taylor Carolyn L.,
Hassid Marc,
Savage Andrew J.,
Atz Andrew M.,
Butts Ryan J.
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12825
Subject(s) - medicine , ventricular function , heart transplantation , cardiology , intensive care medicine , heart failure
Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HT x recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HT x recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA , including EF (−4.2% ±1.2, P < .01) and RV FAC (−0.05 ± 0.02, P = .04). Subjects in the first post‐transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post‐transplant year (n = 8; −6.0% ±1.2 vs −2.1 ± 2.0, P = .1). This information quantifies a decline in biventricular function that should be expected in pediatric HT x recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA ‐induced ventricular dysfunction.