Premium
Role of race in kidney transplant outcomes in children with focal segmental glomerulosclerosis
Author(s) -
Guan Ivan,
Singer Pamela,
Frank Rachel,
Chorny Nataliya,
Infante Lulette,
Sethna Christine B.
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12766
Subject(s) - medicine , race (biology) , transplantation , focal segmental glomerulosclerosis , renal function , kidney transplantation , multivariate analysis , kidney , proteinuria , botany , biology
It is well established that racial differences exist in kidney transplant outcomes; however, there are no studies which focus on the role of race in transplant outcomes specifically in children diagnosed with FSGS . Associations between race and transplant outcomes in FSGS children were evaluated using the Organ Procurement and Transplantation Network database from 2000 to 2012. Recipients aged 2–21 years who received a kidney‐only transplant were included. Multivariate regression models were used to evaluate transplant outcomes by race. Five hundred and thirty‐six recipients (59.7% male, 15.6±3.9 years) were black and 1134 (55.7% male, 14.3±5.0 years) were non‐black. Graft survival was significantly shorter in the black group (4.2±3.1 vs 4.6±3.3 years, P =.005). Black race was associated with significantly higher risk of graft failure ( HR 1.34, 95% CI =1.21–1.49, P <.0001), acute rejection ( OR 1.66 95% CI =1.39–1.97, P <.0001), and delayed graft function ( OR 1.51, 95% CI =1.33–1.72, P <.001) compared to non‐black race. There were no significant differences in mortality, prolonged hospitalization, or FSGS recurrence between groups. Race is a significant predictor for worse transplant outcomes in children with FSGS .