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A paediatric case of successful non‐myeloablative bone marrow transplantation after azacitidine therapy for non‐Down syndrome acute megakaryoblastic leukaemia with monosomy 7
Author(s) -
Koga Yuhki,
Oba Utako,
Kato Wakako,
Ono Hiroaki,
Nakashima Kentaro,
Takada Hidetoshi
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12739
Subject(s) - medicine , azacitidine , acute megakaryoblastic leukemia , monosomy , transplantation , chemotherapy , regimen , chemotherapy regimen , down syndrome , oncology , leukemia , pediatrics , karyotype , psychiatry , biochemistry , gene expression , chemistry , dna methylation , chromosome , gene
We report a patient with non‐Down syndrome AML , also known as AMKL, with monosomy 7, who was also obese and had a hearing impairment and mental retardation. Non‐myeloablative bone marrow transplantation was performed successfully after the patient received less aggressive azacitidine treatment, without the usual intensive induction chemotherapy regimen for AML .