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Resolution of Graves’ disease after renal transplantation
Author(s) -
Lee Yvonne,
Butani Lavjay,
Glaser Nicole,
Nguyen Stephanie
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12709
Subject(s) - medicine , thymoglobulin , tacrolimus , transplantation , immunosuppression , graves' disease , kidney transplantation , subclinical infection , surgery , disease
We report a case of an adolescent boy with Down's syndrome and ESRD on hemodialysis who developed mild Graves’ disease that was not amenable to radioablation, surgery, or ATD s. After 14 months of observation without resolution of Graves’ disease, he successfully received a DDRT with a steroid minimization protocol. Thymoglobulin and a three‐day course of steroids were used for induction and he was started on tacrolimus, MMF , and pravastatin for maintenance transplant immunosuppression. One month after transplantation, all biochemical markers and antibody profiling for Graves’ disease had resolved and remain normal one yr later.