Premium
Polyomaviruses BK , JC , KI , WU , MC , and TS in children with allogeneic hematopoietic stem cell transplantation
Author(s) -
Rahiala Jaana,
Koskenvuo Minna,
Sadeghi Mohammadreza,
Waris Matti,
Vuorinen Tytti,
Lappalainen Maija,
SaarinenPihkala Ulla,
Allander Tobias,
SöderlundVenermo Maria,
Hedman Klaus,
Ruuskanen Olli,
Vettenranta Kim
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12659
Subject(s) - viremia , medicine , hematopoietic stem cell transplantation , subclinical infection , immunology , polyomavirus infections , context (archaeology) , transplantation , bk virus , virology , antibody , biology , paleontology , kidney transplantation
Timely and reliable detection of viruses is of key importance in early diagnosis of infection(s) following allogeneic HSCT . Among the immunocompetent, infections with BKP y V and JCPyV are mostly subclinical, while post‐ HSCT , the former may cause HC and the latter PML . The epidemiology and clinical impact of the newly identified KIPyV , WUPyV , MCPyV , and TSPyV in this context remain to be defined. To assess the incidence and clinical impact of BKPyV , JCPyV , KIPyV , WUPyV , MCPyV , and TSPyV infections, we performed longitudinal molecular surveillance for DNA emias of these HPyV s among 53 pediatric HSCT recipients. Surveillance pre‐ HSCT and for three months post‐ HSCT revealed BKPyV DNA emia in 20 (38%) patients. Our data demonstrate frequent BKPyV DNA emia among pediatric patients with HSCT and the confinement of clinical symptoms to high copy numbers alone. MCPyV and JCPyV viremias occurred at low and TSPyV viremia at very low prevalences. KIPyV or WUPyV viremias were not demonstrable in this group of immunocompromised patients.