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Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation
Author(s) -
Gassas Adam,
Krueger Joerg,
Zaidman Irina,
Schechter Tal,
CraigBarnes Hayley,
Ali Muhammad,
Palaniyar Nades
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12657
Subject(s) - medicine , bronchiolitis obliterans , subclinical infection , pathogenesis , hematopoietic stem cell transplantation , transplantation , immunology , bronchiolitis , respiratory system , gastroenterology , lung transplantation
It is plausible that infections post‐hematopoietic SCT play a role in the pathogenesis of BOS . A prospective study for children with history, questionnaire, examination, PFT s, and blood counts at one, three, six, nine, 12, 18, and 24 months post‐ SCT was conducted. Between September 2009 and September 2011 (n = 39), six developed BOS at 200 days (range 94–282), three patients had probable clinical respiratory infection, and all six had higher neutrophil count compared to non‐ BOS patients (4.7 vs. 2.4 at three months and 6.3 vs. 2.9 at six months ×10 9 /L, p = 0.03). Contribution of clinical and subclinical infection needs to be considered in the pathogenesis of BOS .