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Cytomegalovirus transmission in pediatric renal transplant recipients during the window period
Author(s) -
Gangopadhyay Sanhita,
Rampersaud Howard,
Pelletier J. Peter R.,
Herman Lettie,
Goldstein Steven,
Upadhyay Kiran
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12654
Subject(s) - valganciclovir , medicine , viremia , ganciclovir , cytomegalovirus , window period , renal transplant , plasmapheresis , transmission (telecommunications) , kidney transplantation , immunology , transplantation , gastroenterology , herpesviridae , human cytomegalovirus , virus , viral disease , antibody , serology , electrical engineering , engineering
We report two CMV naïve children who received deceased donor renal transplants from a CMV IgG‐negative single donor. CMV IgG in both recipients and the donor were negative immediately prior to transplant. Both recipients had early recurrences of their original disease in their transplants, requiring multiple sessions of plasmapheresis. All blood products used were leukoreduced or CMV seronegative. A few days post‐transplant, both recipients developed significant positive CMV viremia. Both required initiation of oral valganciclovir. Case 1 responded to oral valganciclovir only while the case 2 had a delayed response to it and hence required intravenous ganciclovir with good response. When checked retrospectively, CMV IgM in the donor was positive along with positive CMV DNA PCR from the white cells. Here we describe a very unusual scenario of CMV transmission in two pediatric renal transplant recipients from a single donor during the CMV window period.