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Results of pediatric living donor compared to deceased donor liver transplantation in the PELD/MELD era: Experience from two centers on two different continents
Author(s) -
Yankol Yucel,
Fernandez Luis A.,
Kanmaz Turan,
Leverson Glen E.,
Mezrich Joshua D.,
Foley David,
Mecit Nesimi,
D'Alessandro Anthony M.,
Acarli Koray,
Kalayoglu Munci
Publication year - 2016
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12641
Subject(s) - medicine , incidence (geometry) , liver transplantation , gastroenterology , surgery , living donor liver transplantation , population , transplantation , physics , environmental health , optics
The LDLT option in the pediatric population allows recipients to be transplanted early. A total of 202 consecutive pediatric liver transplants from two different institutions—108 ( LDLT ) and 94 ( DDLT )—were retrospectively compared. Overall, one‐ and three‐yr patient and graft survival were similar between DDLT and LDLT . ACR was greater in recipients of DDLT at one and three yr (50.8% and 61.0%) compared to LDLT (30.8% and 32.2%) (p = 0.002). When the data were stratified according to PELD / MELD score, LDLT with a low score had better one‐ and three‐yr graft survival (96.2% and 96.2%) compared to DDLT (88.2% and 85.2%) (p = 0.02), with comparable patient survival (p = 0.75). Patient and graft survival were similar between DDLT and LDLT in the high PELD / MELD group. Lower incidence of ACR in both low and high PELD / MELD groups was (29.6% and 34.3%) for LDLT compared to DDLT (50.3% and 53.3%, p = 0.002 and p = 0.028, respectively). Regardless of PELD / MELD score, status, age group, and recipient weight, LDLT provides excellent patient and graft survival with a lower incidence of rejection compared to DDLT .