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Challenging diagnosis and treatment of HIT in child with ventricular assistance device
Author(s) -
Weintraub Lauren,
Driscoll Catherine,
Aydin Scott,
Lamour Jaqueline M.,
Weinstein Sam,
Manwani Deepa
Publication year - 2015
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12540
Subject(s) - medicine , heparin induced thrombocytopenia , thrombosis , antibody , intensive care medicine , clinical practice , heparin , population , titer , immunology , pediatrics , physical therapy , environmental health
HIT presents the clinician with unique diagnostic challenges, especially in the pediatric population. The HIT clinical sequelae of thrombocytopenia and thrombosis are secondary to the activation of platelets by heparin–antibody complexes. Diagnosis involves clinical observations and confirmatory laboratory testing using antibody detection and the functional SRA . As we describe in the following case of a six‐yr‐old female, the SRA may be difficult to interpret in the case of high‐titer antibodies and illustrates the need for repeat testing in cases of high clinical suspicion.