Premium
Pediatric hematopoietic stem cell transplantation in C hina: Data and trends during 1998–2012
Author(s) -
Du Hong,
Chen Jing,
Qin Maoquan,
Fang Jianpei,
Li Zhiguang,
Zhu Yiping,
Sun Xin,
Huang Dongsheng,
Yu Jie,
Tang Yongmin,
Hu Shaoyan,
Li Junhui,
Zhang Zhiquan,
Luan Zuo
Publication year - 2015
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12525
Subject(s) - medicine , hematopoietic stem cell transplantation , incidence (geometry) , transplantation , lymphoma , hematopoietic cell , neuroblastoma , stem cell , haematopoiesis , gastroenterology , pediatrics , physics , optics , biology , genetics , cell culture
The success of treating a wide variety of pediatric diseases with HSCT , hematologic malignancies in particular, has resulted in an increased number of long‐term survivors. This study is the first large‐scale, multicentre report that describes the evolution of pediatric HSCT s in C hina during the period of 1998–2012. Of all 1052 patients, 266 cases were treated with autologous HSC s and 786 used allogeneic HSC s. The disease indications for HSCT s mainly included leukemias, lymphoma, solid tumors, and non‐malignant disorders. The total number of HSCT s, especially unrelated donor transplants, appeared to be increasing year by year. For patients with neuroblastoma, the therapeutic efficacy seemed to be poor, with a five‐yr OS and DFS rate of 34.5 ± 14.3% and 20.7 ± 9.6%, respectively. In contrast, the survival of patients with SAA was prominently improved, and their five‐yr OS and DFS rates were 82.8 ± 4% and 80.7 ± 4.1%, respectively. Patients who received cord blood transplants had a lower incidence of acute GVHD than that of PB and/or BM transplants from unrelated donors. This report offers us a valuable resource for evaluating the changes in HSCT s in C hina over the past 14 yr.