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Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging
Author(s) -
Bolton Scott M.,
Campbell Kathleen M.,
Kukreja Marcia,
Kohli Rohit
Publication year - 2015
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12520
Subject(s) - medicine , urea cycle , liver transplantation , urea , gastroenterology , intensive care medicine , transplantation , biochemistry , chemistry , organic chemistry , amino acid , arginine
Liver transplantation treats the hepatic affectation of UCD s; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict developmental outcomes post‐liver‐transplant in children with UCD s. Methods: Patients undergoing liver transplantation for UCD s at Cincinnati Children's Hospital Medical Center between 2002 and 2012 were identified. Neurologic assessments prior to and after transplantation were categorized into mild, moderate, or severe disability. Neuroimaging data were categorized into mild, moderate, or severe by a single pediatric neuroradiologist. Results: Fifteen patients were identified of whom eight had neuroimaging prior to transplantation. Of the eight patients that had neuroimaging, four were categorized as severe, one moderate, and three no‐to‐mild delay. All four patients whose imaging was severe were found to have moderate‐to‐severe neurologic delay. Of the three patients with no‐to‐mild changes on neuroimaging two of three were found to have no‐to‐mild delay on developmental assessments after transplantation. Conclusion: Neuroimaging may be a helpful tool in determining developmental prognosis and outcomes post‐liver‐transplantation for UCD s. Further studies maybe needed to validate our preliminary findings.