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Sirolimus‐induced interstitial lung disease following pediatric stem cell transplantation
Author(s) -
Garrod Andrea S.,
Goyal Rakesh K.,
Weiner Daniel J.
Publication year - 2015
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12438
Subject(s) - medicine , sirolimus , interstitial lung disease , hypoxemia , complication , transplantation , lung transplantation , lung , stem cell , adverse effect , pulmonary function testing , intensive care medicine , surgery , biology , genetics
Sirolimus‐induced ILD is a known but rare complication in adults who have undergone SOT . However, little is known about this adverse effect in children. Diagnosis of sirolimus‐induced ILD can be challenging, especially in patients who have difficulty participating in lung function testing. We present a case of presumed sirolimus‐induced ILD in a pediatric stem cell transplant patient who developed polycythemia and hypoxemia. To our knowledge, no other cases of sirolimus‐induced pulmonary toxicity in children after HCT have been reported.