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Clinical comparison of weight‐ and age‐based strategy of dose administration in children receiving intravenous busulfan for hematopoietic stem cell transplantation
Author(s) -
Gürlek Gökçebay D.,
Azik F.,
Ozbek N.,
Isik P.,
Avci Z.,
Tavil B.,
Kara A.,
Tunc B.
Publication year - 2015
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12430
Subject(s) - medicine , busulfan , dosing , transplantation , hematopoietic stem cell transplantation , incidence (geometry) , hematology , toxicity , gastroenterology , surgery , physics , optics
B u, combined with TDM ‐guided dosing, is associated with fewer graft failures/relapses and lower toxicity in pediatric HSCT . We aimed this retrospective study for comparison of weight‐ and age‐based dosing in terms of clinical outcomes such as time to engraftment, early complications, EFS , OS , and toxicity profiles in children receiving iv B u. Sixty‐one children who underwent HSCT from April 2010 to February 2013 by means of a Bu‐based conditioning regimen and completed 100 days after transplantation at Ankara Children?s Hematology and Oncology Hospital Bone Marrow Transplantation Unit were enrolled in this study. SOS and neutropenic fever occurred more frequently in the weight‐based dosing group. We found a statistically significant correlation between B u dose and the incidence of SOS ( r = 0.26, p = 0.04). Multivariate analysis showed only weight‐based dosing of B u was a significant predictor of SOS ( HR = 9.46; p = 0.009). However, no relationship was found between two groups in terms of hemorrhagic cystitis, engraftment syndrome, acute or chronic G v HD , time to engraftment, chimerism, TRM , OS , and EFS rates. Weight‐based dosing of B u may cause higher incidence of SOS and early infectious complications at the places where TDM of B u cannot be performed.