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High‐risk age window for mortality in children with cystic fibrosis after lung transplantation
Author(s) -
Hayes Don,
McCoy Karen S.,
Whitson Bryan A.,
Mansour Heidi M.,
Tobias Joseph D.
Publication year - 2015
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12401
Subject(s) - medicine , hazard ratio , proportional hazards model , confounding , cystic fibrosis , lung transplantation , transplantation , demography , surgery , confidence interval , sociology
LT x in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post‐transplant mortality was plotted over attained age to identify age window of highest risk, which was 16–20 yr. Unadjusted PCHR model revealed ages immediately after the high‐risk window were characterized by lower hazard of mortality ( HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high‐risk window remained statistically significant ( HR = 0.394; 95% CI : 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LT x was highest between 16 and 20 yr of attained age and declined thereafter.