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De novo amyloidosis in a renal transplant patient
Author(s) -
Yılmaz Songül,
Özçakar Z. Birsin,
Bulum Burcu,
Kiremitçi Saba,
Ensari Arzu,
Ekim Mesiha,
Keven Kenan,
Yalçınkaya Fatoş
Publication year - 2014
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12344
Subject(s) - medicine , amyloidosis , transplantation , proteinuria , renal biopsy , aa amyloidosis , kidney transplantation , complication , genitourinary system , end stage renal disease , kidney , pathology , gastroenterology , disease , familial mediterranean fever
Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders and chronic infections. Renal involvement is seen in the majority of the patients and can lead to end‐stage renal disease. Renal transplantation can be performed in these patients; however, amyloidosis can recur in the transplanted kidneys. On the other hand, de novo AA amyloidosis in renal transplant patients has been rarely reported. We report a 17‐yr‐old patient with end‐stage renal disease due to genitourinary anomalies who developed recurrent pyelonephritis after transplantation. Three yr after transplantation, renal biopsy was performed for proteinuria and AA amyloidosis was identified in the renal allograft. Although rare, chronic infections might cause de novo amyloidosis in renal transplant patients. Therefore, amyloidosis should be kept in mind in those types of patients who present with proteinuria.