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Necessary stem cell transplantation using myeloablative therapy for myelodysplastic syndrome with progression of genotypic abnormalities and TP 53 dysfunction in a young adult
Author(s) -
Sato Yuya,
Kurosawa Hidemitsu,
Fukushima Keitaro,
Okuya Mayuko,
Yabe Hiromasa,
Arisaka Osamu
Publication year - 2014
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12334
Subject(s) - medicine , stem cell , oncology , myelodysplastic syndromes , abnormality , transplantation , genotype , karyotype , bone marrow , gene , chromosome , genetics , psychiatry , biology
Abstract A 14‐yr‐old male was admitted to our hospital with MDS and the chromosomal abnormality 45, XY ,der(5;17)(p10;q10). He rapidly developed karyotype abnormalities, accompanied by the loss of tumor suppressor gene TP 53 function. He suffered an early relapse after reduced‐intensity‐conditioning SCT and ultimately required myeloablative therapy before a second SCT . We consider that the analysis of TP 53 mutations is essential when planning the treatment of patients with MDS .