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Pediatric transplantation and tolerance: Past, present, and future
Author(s) -
Kamran Hejazi Kenari Seyed,
Mirzakhani Hooman,
Saidi Reza F.
Publication year - 2014
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12301
Subject(s) - medicine , intensive care medicine , transplantation , organ transplantation , surgery
Solid organ transplantation is the treatment of choice in children with end‐stage organ failure. With improving methods of transplant surgery and post‐transplant care, transplantation is more frequently performed worldwide. However, lifelong and non‐specific suppression of the recipient's immune system is a cause of significant morbidity in children, including infection, diabetes, and cancer. There is a great need to develop IS minimization/withdrawal and tolerance induction approaches.