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Successful lung transplant in a child with cystic fibrosis and persistent Blastobotrys rhaffinosifermentans infection
Author(s) -
Wong J. Y.,
Chambers A. L.,
Fuller J.,
Lacson A.,
Mullen J.,
Lien D.,
Humar A.
Publication year - 2014
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12294
Subject(s) - medicine , cystic fibrosis , colonization , lung transplantation , lung , antifungal , transplantation , intensive care medicine , pediatrics , immunology , microbiology and biotechnology , dermatology , biology
Fungal respiratory infections in patients with CF are a significant concern both pre‐ and post‐lung transplantation ( LT x). Fungal infection is associated with increased mortality post‐ LT x, and in the past decade, the prevalence of fungal colonization in Canadian pediatric patients with CF has increased. The emergence of novel fungal pathogens is particularly challenging to the transplant community, as little is known regarding their virulence and optimal management. We present a case of a successful double‐lung transplant in a pediatric patient with CF who was infected pretransplantation with a novel yeast, Blastobotrys rhaffinosifermentans . This patient was treated successfully with aggressive antifungal therapy post‐transplantation, followed by extended fungal prophylaxis. The significance of fungal colonization and infection in children with CF pre‐ and post‐ LT x is reviewed.