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Delayed graft function in pediatric deceased donor kidney transplantation: Donor‐related risk factors and impact on two‐yr graft function and survival: A single‐center analysis
Author(s) -
Cesca Eleonora,
Ghirardo Giulia,
Kiblawi Rim,
Murer Luisa,
Gamba Piergiorgio,
Za Giovanni Franco
Publication year - 2014
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12252
Subject(s) - medicine , single center , multivariate analysis , univariate analysis , surgery , transplantation , population , kidney transplantation , resuscitation , risk factor , environmental health
There is mounting evidence that the quality of organs from cadaver donors may be influenced by events occurring around the time of brain death. Aim of this present study was to analyze the correlation of DGF with brain‐dead donor variables in a single‐center pediatric population and to evaluate DGF influence on patients‐ and grafts outcome. End‐points of the study were DGF prevalence, DGF donor‐related risk factors, graft function, patient‐ and graft survival rate, respectively, at six, 12, and 24 months FU . The univariate analysis showed that donor age above 15 yr and vascular cause of donor brain death represented risk factors for DGF . The multivariate analysis confirmed as independent risk factors for DGF donor age >15 yr. At six months FU , DGF showed a negative impact on graft function. In conclusion, among all considered brain‐dead donor resuscitation parameters, just non‐traumatic cause of death turned out to be of impact for DGF . Donor age >15 yr represented the only independent risk factor for prolonged DGF in our series of children. At two‐yr FU , DGF showed a transient negative impact on six‐month graft function.