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Solid tumors following kidney transplantation in children
Author(s) -
Smith Jodi M.,
Martz Karen,
McDonald Ruth A.,
Harmon William E.
Publication year - 2013
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12166
Subject(s) - medicine , malignancy , immunosuppression , transplantation , population , incidence (geometry) , cohort , renal cell carcinoma , risk factor , kidney disease , etiology , kidney transplantation , pediatrics , physics , environmental health , optics
Kidney transplant recipients have an increased risk of cancer. Data on non‐ LPD malignancies (solid tumors) in pediatric renal transplant recipients are limited. We performed a cohort study using the NAPRTCS transplant registry to describe the incidence of non‐ LPD malignancy compared with the general pediatric population. The observed incidence rate of non‐ LPD malignancy in the NAPRTCS transplant registry was 72.1 per 100 000 person‐years ( SIR 6.7; 95% CI , 5.3, 8.5); a 6.7‐fold increased risk compared with the general pediatric population (10.7 cases per 100 000 person‐years). Non‐ LPD malignancy was diagnosed in 35 subjects at a median of 726 days post‐transplant. The most common type of malignancy was renal cell carcinoma. The increased risk of non‐ LPD malignancy was seen in all patients regardless of age, gender, race, etiology of end‐stage kidney disease, and transplant era. The specific type of immunosuppression was not identified as a risk factor. In this first large‐scale study of N orth A merican pediatric renal transplant recipients, we observed a 6.7‐fold increased risk of non‐ LPD malignancy compared with the general pediatric population. Further examination of this unique patient population may provide greater insight into the impact of transplant and immunosuppression on malignancy risk.