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Delayed short‐term administration of granulocyte colony‐stimulating factor is a good mobilization strategy for harvesting autologous peripheral blood stem cells in pediatric patients with solid tumors
Author(s) -
Takahashi Hiroyoshi,
Kato Motohiro,
Kikuchi Akira,
Hanada Ryoji,
Koh Katsuyoshi
Publication year - 2013
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12137
Subject(s) - medicine , granulocyte colony stimulating factor , chemotherapy , mobilization , granulocyte , stem cell , surgery , peripheral blood , genetics , archaeology , history , biology
PBSC s have become the preferred source of autologous stem cells for supporting high‐dose chemotherapy in childhood solid tumors. The aims of this retrospective study were to examine the optimal timing for administration of G ‐ CSF after chemotherapy and to identify the patients from whom an optimal dose of PBSC s can be harvested. We evaluated the timing of G ‐ CSF administration for harvesting PBSC s in patients with childhood solid tumors. G ‐ CSF was administered immediately after chemotherapy in eight patients (11 harvests, long‐term group) and following recovery from hematological nadirs in 17 patients (21 harvests, short‐term group). The median duration of G ‐ CSF administration was 22 vs. 5 days, respectively (p < 0.005), and the dose of harvested CD 34 + cells (×10 6 /kg) was 1.4 vs. 2.9, respectively (p = 0.023). Our results suggest that short‐term G ‐ CSF administration is a good strategy for harvesting PBSC s in these patients.