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Micronutrient deficiencies in pediatric and young adult intestinal transplant patients
Author(s) -
Ubesie Agozie C.,
Cole Conrad R.,
Nathan Jaimie D.,
Tiao Greg M.,
Alonso Maria H.,
Mezoff Adam G.,
Henderson Carol J.,
Kocoshis Samuel A.
Publication year - 2013
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12132
Subject(s) - micronutrient , medicine , micronutrient deficiency , transplantation , malnutrition , pediatrics , risk factor , short bowel syndrome , parenteral nutrition , gastroenterology , surgery , pathology
Intestinal transplant recipients are at risk of micronutrient deficiency due to the slow process of post‐transplant adaptation. Another contributing factor is calcineurin inhibitor–induced renal tubular dysfunction. Patients are typically supplemented with micronutrients during PN; however, the risk of deficiency may persist even after a successful transition to FEN. The goal was to determine the prevalence of, and associated risk factors for, iron, zinc, magnesium, phosphorus, selenium, copper, folate, and vitamins A, D, E, and B12 deficiency in pediatric intestinal transplant recipients after successful transition to FEN. A retrospective review of prospectively collected data from children who underwent intestinal transplantation at Cincinnati Children's Hospital Medical Center was done. Deficiencies of various micronutrients were defined using the hospital reference values. Twenty‐one intestinal transplant recipients, aged one to 23 yr, who were successfully transitioned to FEN were included in the study. The prevalence of micronutrient deficiency was 95.2%. The common deficient micronutrients were iron (94.7%) and magnesium (90.5%). Age ≤ 10 yr (p = 0.002) and tube feeding (p = 0.02) were significant risk factors for micronutrient deficiencies. Pediatric intestinal transplant recipients have a high risk of micronutrient and mineral deficiencies. These deficiencies were more common among younger patients and those who received jejunal feeding.