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Clinical effectiveness of early treatment with hyperbaric oxygen therapy for severe late‐onset hemorrhagic cystitis after hematopoietic stem cell transplantation in pediatric patients
Author(s) -
Zama Daniele,
Masetti Riccardo,
Vendemini Francesca,
Di Donato Ferruccio,
Morelli Alessandra,
Prete Arcangelo,
Pession Andrea
Publication year - 2013
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12031
Subject(s) - medicine , hemorrhagic cystitis , hematopoietic stem cell transplantation , concomitant , hyperbaric oxygen , surgery , transplantation , pediatrics , anesthesia
HC is a possible cause of morbidity and extended hospitalization after HSCT . Recent studies have reported the efficiency of HOT in adult patients who underwent allogeneic HSCT , but data in children are scarce. We report our single center experience with HOT in late‐onset HC after HSCT . Treatment with HOT consisted of daily sessions of breathing 100% O 2 for a total of 75 min in the hyperbaric chamber with a minimum of eight sessions. HOT had been associated with a concomitant treatment with oral oxybutynin, hyperhydration and/or irrigation of the bladder through the catheter. Cidofovir had been administered based on the demonstration of viral infection. Between 2004 and 2011, 10 patients developed severe HC after a median of 26 days after HSCT . HOT was started after a median of six days since the clinical diagnosis of HC . After a median of 10 sessions of HOT , seven of 10 patients were in complete remission. HOT is a well‐tolerated procedure also in the pediatric setting. The early start of HOT might be effective in the treatment of HC offering advantages in terms of duration of symptoms and hospitalization.