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Acute graft‐versus‐host disease in pediatric allogeneic hematopoietic stem cell transplantation. Single‐center experience during 10 yr
Author(s) -
Faraci Maura,
Caviglia Ilaria,
Biral Erika,
Morreale Giuseppe,
Giardino Stefano,
Garbarino Lucia,
Castagnola Elio,
Dini Giorgio,
Lanino Edoardo
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12009
Subject(s) - medicine , incidence (geometry) , cumulative incidence , single center , malignancy , hematopoietic stem cell transplantation , transplantation , gastroenterology , complication , retrospective cohort study , graft versus host disease , surgery , disease , pediatrics , physics , optics
a‐ G v HD may complicate allogeneic HSCT . In this retrospective single‐center study, we evaluated incidence and risk factors of a‐ G v HD in 197 consecutive allogeneic pediatric HSCT s applying G lucksberg and NIH a‐Gv HD classifications. Among 179 eligible transplants, the cumulative incidence of grade 0–I a‐ G v HD was 48% and grade II – IV was 52%. None of the considered variables significantly influenced the incidence of grade II – IV a‐ G v HD . Malignancy and myeloablation were associated with an increased risk of classic a‐ G v HD (p < 0.01). Seventy‐two percentage of children are alive, with a significant difference in OS and TRM between grade 0 and I vs. grade II and IV a‐ G v HD ; this observation was reproduced in the non‐malignant setting, while only a disparity in TRM was evidenced in children with malignancy. In our experience, the incidence of a‐ G v HD was similar, regardless of donor type. Myeloablation and malignant disease represented the only risk factors for classic a‐ G v HD . Our results highlight the need for a better prevention of this complication in the non‐malignant setting.