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Lipid metabolism and oxidative stress in children after liver transplantation treated with sirolimus
Author(s) -
Jankowska Irena,
Czubkowski Piotr,
Socha Piotr,
Wierzbicka Aldona,
Teisseyre Mikołaj,
Teisseyre Joanna,
Pawłowska Joanna
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/petr.12007
Subject(s) - medicine , endocrinology , oxidative stress , cholesterol , lipid metabolism , glutathione , transplantation , metabolism , lipoprotein , biochemistry , chemistry , enzyme
Abstract Lipid disturbances are one of the most frequent side effects of SRL ; however, clinical consequences are not known. The aim of the study was to evaluate the risk of AS in children after LT x treated with SRL . In 17 children with median age 13.2 yr (1.9–17.9) who received SRL on average for 4.1 yr (s.d. ± 2.9) we measured and compared with age‐matched healthy control group (n = 45) lipid parameters and markers of AS : ADMA , oxy LDL , GSH , GP x, TC , TG , HDL cholesterol, LDL cholesterol, VLDL cholesterol, A po AI , A po B , A po E , lipoprotein (a) ( L p(a)). We found no major differences in cholesterol, cholesterol in lipoprotein fractions and TG concentrations between patients receiving SRL and the control group. A po E was markedly increased in the study group (19.1 g/L [±1.8]) when compared to controls (9.8 [±3.9]). A po A 1 was decreased in the study group: 1.30 g/L (±0.2) vs. 1.45 (±0.25), p = 0.04. A po B and L pa concentrations were similar in both groups. There were differences in oxidative stress markers: GSH 743 (±66.2) mol/mL vs. 780 (±48.2), p = 0.02 and GP x 32.8 (±5.5) U / gH b vs. 34.3(±2.6), p = 0.01. Markers of AS : ADMA did not differ between groups and oxidized LDL c was significantly lower in SRL group: 190 mU /mL (±113) vs. 237 (±107) in control, p < 0.05. SRL does not significantly disturb lipid metabolism and oxidative status in children after LT x.