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Monogenic diabetes: A single center experience from South India
Author(s) -
Lakshmanan Nivethitha Karthika,
Pavithran Praveen V,
Bhavani Nisha,
Abraham Nithya,
Kumar Harish,
Nair Vasantha,
Me Usha,
Me Arun S,
Narayanan Prem,
Lakshmi Geetha
Publication year - 2021
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.13040
Subject(s) - medicine , diabetes mellitus , wolfram syndrome , pediatrics , megaloblastic anemia , population , anemia , endocrinology , environmental health
Monogenic forms of diabetes in children are frequently misclassified as either type 1 diabetes or young‐onset type 2 diabetes. There is a paucity of literature regarding pediatric monogenic diabetes in the Indian population. A retrospective analysis of case records of 37 children with monogenic diabetes who were diagnosed between 2008 and 2019 in a South Indian tertiary care center was performed. The write‐up describes the clinical, biochemical, and genetic characterization of these patients with the diagnoses of neonatal diabetes mellitus (15 patients), MODY (five patients), and various forms of syndromic diabetes (13 with Wolfram syndrome, two with H syndrome, one with mitochondrial diabetes, and one with thiamine responsive megaloblastic anemia).