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Regular physical activity as a physiological factor contributing to extend partial remission time in children with new onset diabetes mellitus—Two years observation
Author(s) -
JamiołkowskaSztabkowska Milena,
GłowińskaOlszewska Barbara,
Łuczyński Włodzimierz,
Konstantynowicz Jerzy,
Bossowski Artur
Publication year - 2020
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.13018
Subject(s) - medicine , diabetes mellitus , anthropometry , type 1 diabetes , pediatrics , metabolic control analysis , insulin , endocrinology
Background Beneficial effects of physical activity (PA) are confirmed in patients with all types of long‐lasting diabetes. The possibility of PA to be a factor prolonging remission phase in children with new‐onset type 1 diabetes (T1D) has not yet been thoroughly studied. Objective The aim of the study was to elucidate the influence of regular PA on prevalence of partial remission (PR), metabolic control, daily insulin requirement (DIR), and C‐peptide secretion in children newly diagnosed with T1D. Methods A total of 125 children diagnosed with T1D were studied prospectively for 2 years. Patients were controlled every 3 months and advised with PA according to ISPAD recommendations. Anthropometric parameters, HbA1c, C‐peptide level and DIR were analyzed. Patients' PA level was assessed using a self‐designed questionnaire. Results We classified 43% of participants as physically‐active. In this group, lower HbA1c after 2 years, lower DIR after 3, 6 months, and after 2 years (all P < .05) were found. At discharge from hospital, the prevalence of DIR < 0.5 U/kg/24 h with near normoglycemia was similar in both groups. Then, we observed higher PR prevalence in active group lasting over time and resulting in 44% vs 13% after 2 years ( P < .001). C‐peptide after 2 years was comparable in both groups, with higher prevalence of clinically significant levels (>0.2 nmoL/L) in active group: 79.6% vs 61.4% ( P = .029). Conclusions These data support the view that regular PA may essentially contribute to extending PR time in pediatric diabetes, and may therefore lead to a better long‐term metabolic control of the disease.