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Osteopontin as a marker of vasculopathy in pediatric patients with type 1 diabetes mellitus: Relation to vascular structure
Author(s) -
Abo ElAsrar Mohamed,
Ismail Eman Abdel Rahman,
Thabet Rasha Adel,
Kamel Ashraf Sayed,
NehmedAllah Sameh
Publication year - 2018
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12686
Subject(s) - medicine , osteopontin , intima media thickness , diabetes mellitus , diabetic nephropathy , type 2 diabetes mellitus , type 1 diabetes , cardiology , subclinical infection , c reactive protein , creatinine , endocrinology , gastroenterology , carotid arteries , inflammation
Background Type 1 diabetes mellitus (T1DM) is associated with serious micro‐vascular and macro‐vascular complications. Osteopontin (OPN) has emerged as a strong predictor of incipient diabetic nephropathy and a first‐ever cardiovascular event in adults with T1DM. OPN is linked to coronary atherosclerosis in type 2 diabetes. The aim of the study was to test the hypothesis that OPN could be a potential marker for micro‐vascular complications in children and adolescents with T1DM and we assessed its relation to carotid and aortic intima media thickness (CIMT and AIMT) as non‐invasive index for subclinical atherosclerosis. Methods Eighty patients with T1DM ≤18 years were divided into 2 groups according to the presence of micro‐vascular complications and compared with 40 age‐ and sex‐matched healthy controls. Fasting blood glucose, high sensitivity C‐reactive protein (hs‐CRP), HbA1c, urinary albumin creatinine ratio (UACR), OPN, CIMT, and AIMT were assessed. Results Both CIMT and AIMT were significantly higher in patients with and without micro‐vascular complications compared with healthy controls ( P < .001). OPN concentrations were significantly elevated in all diabetic patients compared with controls ( P = .002). OPN was also significantly higher in patients with micro‐vascular complications than patients without ( P < .001) but levels were comparable among those without complications and controls ( P = .322). Receiver operating characteristic curve analysis revealed that OPN cut‐off value 90 ng/mL could differentiate patients with and without micro‐vascular complications with 81.7% sensitivity and 95.8% specificity. Significant positive correlations were found between OPN and HbA1c, UACR, CIMT, and AIMT. Conclusions OPN could be considered a marker of vasculopathy and subclinical atherosclerosis in pediatric T1DM.