Premium
Effects of insulin resistance on the association between the circulating retinol‐binding protein 4 level and clustering of pediatric cardiometabolic risk factors
Author(s) -
Lin WeiTing,
Lin PeiChen,
Lee ChunYing,
Chen YiLing,
Chan TeFu,
Tsai Sharon,
Huang HsiaoLing,
Wu PeiWen,
Chin YuTing,
Lin HuiYi,
Lee ChienHung
Publication year - 2018
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12639
Subject(s) - insulin resistance , medicine , waist , metabolic syndrome , homeostatic model assessment , retinol binding protein 4 , endocrinology , triglyceride , obesity , cholesterol , adipokine
Objectives Retinol‐binding protein 4 (RBP4) and insulin resistance (IR) are clinical parameters associated with cardiometabolic diseases. The mediating and modifying roles of IR on children’s susceptibility to cardiometabolic disorders are undetermined. This study investigated the mediating and modifying effects of the homeostatic model assessment of IR (HOMA‐IR) on the relationship between the serum RBP4 level and clustering of pediatric cardiometabolic risk factors. Methods We assessed the diet, physical activity, cardiometabolic risk factors, and clinical parameters of 272 randomly selected adolescents from a large‐scale cross‐sectional study ( n = 2727). Two HOMA‐IRs (HOMA1‐IR and HOMA2‐IR) were used to evaluate the designated effects. Results Levels of serum RBP4 positively correlated with the levels of the 2 HOMA‐based‐IRs, and HOMA‐IR correlated to all components of pediatric metabolic syndrome (MetS), the number of abnormal components, and a body‐weight‐weighted principal component score extracted from 12 cardiometabolic risk factors. Increased RBP4 levels had positive effects on waist circumference (WC), triglyceride, and the number of abnormal MetS components (0.310 cm, 1.384 μg/dL, and 0.021 item elevations, respectively), and the HOMA‐IRs explained 17.7% to 21.9%, 11.8% to 27.6%, and 23.8% to 25.0% of these effects. The association of WC and the number of abnormal MetS components with the serum RBP4 level was enhanced by higher HOMA‐IR ( β for interaction, 0.13 and 0.01 for HOMA1‐IR, and 0.32 and 0.02 for HOMA2‐IR, respectively). Conclusions HOMA‐IR is associated with the circulating RBP4 level and cardiometabolic risk factors in adolescents. Pediatric HOMA‐IR may have mediating and modifying effects on the positive correlations between RBP4 and the clustering of MetS components.