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Thrombocytopenia‐associated multi‐organ failure secondary to hyperglycemic, hyperosmolar non‐ketotic syndrome: A case report
Author(s) -
TufanPekkucuksen Naile,
Gazzaneo Maria Carolina,
Afonso Natasha Susana,
Swartz Sarah J,
Angelo Joseph R,
Srivaths Poyyapakkam
Publication year - 2018
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12608
Subject(s) - medicine , diabetic ketoacidosis , intensive care unit , intensive care medicine , presentation (obstetrics) , pediatrics , diabetes mellitus , critically ill , mortality rate , intensive care , paediatric intensive care unit , surgery , endocrinology
Thrombocytopenia associated multi‐organ failure (TAMOF) is a clinical syndrome with features of new onset thrombocytopenia, increased lactate dehydrogenase, and multi‐organ failure in critically ill patients. TAMOF can be the initial presentation of an underlying disease process or can develop during the course of illness either during the hospital stay. TAMOF has a high mortality rate if not treated; therefore, early detection is critical. TAMOF has been rarely reported in diabetic ketoacidosis. We are describing the first case of a patient diagnosed with hyperglycemic, hyperosmolar non‐ketotic syndrome who developed TAMOF on the third day of his hospital course. In addition to supportive care in the intensive care unit the patient received serial therapeutic plasma exchanges and improved quickly after treatment. Early diagnosis and treatment of TAMOF decreases morbidity and mortality.