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Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors
Author(s) -
AlíasHernández Irene,
GaleraMartínez Rafael,
GarcíaGarcía Emilio,
MuñozVico Francisco Javier,
Vázquez Lopez María Ángeles,
OlveraPorcel María Carmen,
Bonillo Perales Antonio
Publication year - 2018
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12533
Subject(s) - medicine , insulin resistance , population , pediatrics , insulin , environmental health
Background The aim of this study is to determine values of insulinaemia, homeostasis model assessment ( HOMA ) index and quantitative insulin sensitivity check index ( QUICKI ) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance ( IR ), and to study its association with cardiovascular risk factors. Materials and Methods Population‐based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9.99 years old. Anthropometric measurements, blood pressure, and fasting blood samples were obtained, including fasting glucose, triglycerides, High Density Lipoprotein (HDL) ‐cholesterol, and insulin. In addition, QUICKI and HOMA indices were calculated. Generalised additive models for location, scale and shape ( GAMLSS ) was used to calculate centiles curves and multivariate logistic regression analysis to assess factors associated with IR . Results A total of 654 subjects were included. Mean values obtained for insulinaemia, HOMA index, and QUICKI were 3.74 μIU / mL , 0.73, and 0.44, respectively, in the overall population and 3.32 μIU / mL , 0.64 and 0.46, respectively, in normal weight subjects. The main factor associated with IR was abdominal obesity (odds ratio [ OR ] 3.38 [95% CI 1.44‐7.94] in the subgroup aged 2.00‐5.99 years and OR 9.14 [3.42‐24.41] for those aged 6.00‐9.99 years). An increased risk of hyperglycaemia ( P = 0.043), hypertriglyceridaemia ( P < .001), and HDL < p 10 ( P = 0.021) was described among children aged 2.00 to 5.99 years with IR , and among those aged 6.00 to 9.99 years, IR was associated with an increased risk of hypertriglyceridaemia ( P < .001). Conclusion Abdominal obesity was the main factor associated with IR . Metabolic changes associated with IR seem to be present from early stages of life, which highlights the importance of the prevention, early diagnosis and treatment of obesity.