Premium
Severe hypoglycemia rates are not associated with HbA1c : a cross‐sectional analysis of 3 contemporary pediatric diabetes registry databases
Author(s) -
Haynes Aveni,
Hermann Julia M.,
Miller Kellee M.,
Hofer Sabine E.,
Jones Timothy W.,
Beck Roy W.,
Maahs David M.,
Davis Elizabeth A.,
Holl Reinhard W.
Publication year - 2017
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12477
Subject(s) - medicine , hypoglycemia , diabetes mellitus , glycemic , glycated hemoglobin , type 1 diabetes , pediatrics , type 2 diabetes , regimen , endocrinology
Objective To examine the association between glycated hemoglobin ( HbA1c ) and severe hypoglycemia rates in patients with type 1 diabetes receiving usual care, by analysing data from the US Type 1 Diabetes Exchange ( T1DX ), German/Austrian Diabetes Patienten Verlaufsdokumenation ( DPV ), and Western Australian Children Diabetes Database ( WACDD ) diabetes registries. Methods Data for patients with type 1 diabetes, aged <18 years with a minimum duration of diabetes of 2 years, were extracted from each registry for a 12‐month observation period between 2011 and 2012 (7,102 T1DX , 18,887 DPV , and 865 WACDD ). Rates of severe hypoglycemia (self‐reported loss of consciousness/convulsion) were estimated per 100 patient‐years and analyzed by HbA1c , source registry, treatment regimen, and age group. Results Overall, the severe hypoglycemia rate per 100 patient years was 7.1, 3.3, and 6.7 in T1DX , DPV , and WACDD patients, respectively. Lower HbA1c was not associated with an increased rate of severe hypoglycemia when examined by source registry, treatment regimen, or age group. Conclusion An inverse relationship between mean HbA1c and risk of severe hypoglycemia was not observed in this study of 3, independent cohorts of children and adolescents with type 1 diabetes. Investigation in other large, longitudinal cohorts is recommended to further characterize the contemporary relationship between glycemic control and risk of severe hypoglycemia rates in pediatric patients with type 1 diabetes.