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Race or vitamin D: A determinant of intima media thickness in obese adolescents?
Author(s) -
Bacha Fida,
Arslanian Silva A.
Publication year - 2017
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12472
Subject(s) - medicine , intima media thickness , vitamin d and neurology , endocrinology , blood pressure , obesity , vitamin d deficiency , carotid arteries
Objective Carotid intima media thickness (IMT), a predictor of cardiovascular events, is reported to be higher in African‐American (AA) vs White (AW) individuals. We investigated whether racial differences in IMT in obese adolescents could be explained by differences in 25 hydroxy‐vitamin D [25(OH)D]. Research Design and Methods A total of 63 obese adolescents had 25(OH)D levels, determination of IMT, body composition, insulin sensitivity (IS) by hyperinsulinemic‐euglycemic clamp, lipids and blood pressure (BP). Results IMT was higher and 25(OH)D lower in AA vs AW. IMT correlated with 25(OH)D level ( r = −0.38, P = .002) but not with IS. In multiple regression analysis, race, HbA1c, BP and age, and not 25(OH)D, BMI or IS, were the significant determinants of IMT (R 2 = 0.44, P < .001). Without race in the model, 25(OH)D (β = −0.36, P = .009) contributed to the variance in IMT (R 2 = 0.32, P = .007). Conclusion Obese AA adolescents vs AW, have higher IMT, explained by race, BP, and HbA1c. Although 25(OH)D levels contribute to the variance in IMT, the observed racial difference in IMT could be mediated through other unknown race‐related factors besides 25(OH)D.