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A description of clinician reported diagnosis of type 2 diabetes and other non‐type 1 diabetes included in a large international multicentered pediatric diabetes registry ( SWEET )
Author(s) -
Pacaud Danièle,
Schwandt Anke,
Beaufort Carine,
Casteels Kristina,
Beltrand Jacques,
Birkebaek Niels H.,
Campagnoli Myrna,
Bratitasa,
Limbert Catarina,
MP O'Riordan Stephen,
Ribeiro Rogério,
GerasimidiVazeou Andriani,
Petruzelkova Lenka,
Verkauskiene Rasa,
Krisane Iveta Dzivite
Publication year - 2016
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12426
Subject(s) - medicine , diabetes mellitus , type 1 diabetes , type 2 diabetes , population , pediatrics , cystic fibrosis related diabetes , etiology , endocrinology , impaired glucose tolerance , environmental health
Background Although type 1 diabetes ( T1D ) remains the most frequent form of diabetes in individuals aged less than 20 years at onset, other forms of diabetes are being increasingly recognized. Objectives To describe the population of children with other forms of diabetes (non‐type 1) included in the multinational SWEET (Better control in Pediatric and Adolescent diabete S: W orking to cr E ate C E n T ers of Reference) database for children with diabetes. Methods Cases entered in the SWEET database are identified by their physician as T1D , type 2 diabetes ( T2D ) and other types of diabetes according to the ISPAD classification. Etiologic subgroups are provided for other types of diabetes. Descriptive analyses were tabulated for age at onset, gender, daily insulin doses, and hemoglobin A1c ( A1C ) for each type and subtype of diabetes and when possible, values were compared. Results Of the 27 104 patients included in this report, 95.5% have T1D , 1.3% T2D , and 3.2% other forms of diabetes. The two most frequent etiologies for other forms of diabetes were maturity onset diabetes of the young ( MODY ) ( n = 351) and cystic fibrosis‐related diabetes ( CFRD ) ( n = 193). The cause was unknown or unreported in 10% of other forms of diabetes. Compared with T1D , children with T2D and CFRD were diagnosed at an older age, took less insulin and had lower A1C (all P < .0001). Conclusion In centers included in SWEET , forms of diabetes other than type 1 remain rare and at times difficult to characterize. Sharing clinical information and outcome between SWEET centers on those rare forms of diabetes has the potential to improve management and outcome.