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Serum oxidized low‐density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents
Author(s) -
MorellAzanza Lydia,
GarcíaCalzón Sonia,
RendoUrteaga Tara,
MartinCalvo Nerea,
Chueca Maria,
Martínez José Alfredo,
AzconaSanjulián Maria Cristina,
Marti Amelia
Publication year - 2017
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12405
Subject(s) - medicine , weight loss , obesity , low density lipoprotein , endocrinology , pediatrics , cholesterol
Background and aims The oxidation of low‐density lipoprotein ( LDL ) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL ( oxLDL ) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods Forty obese children (mean age 11 years, 51% boys) followed a 10‐week weight loss program. They were dichotomized at the median of body mass index‐standard deviation score ( BMI‐SDS ) change, as high ( HR ) and low responders ( LR ) after the intervention. The intervention included a moderate energy‐restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score ( CMS ) was calculated considering metabolic risk factors. Results Higher baseline oxLDL levels were associated with a higher CMS in obese children ( P < .001). After the intervention, oxLDL significantly decreased in the HR group. Moreover, a positive correlation between changes in oxLDL and BMI‐SDS ( r = 0.385, P = .015) was found after the weight loss program. Interestingly, multiple‐adjusted regression models showed an association between changes in total cholesterol [ B : 0.127, 95% confidence interval ( CI ): 0.06 to 0.20] and LDL ‐cholesterol ( B : 0.173, 95% CI : 0.08 to 0.26) with changes in oxLDL . Conclusions Higher baseline oxLDL levels were associated with a higher CMS in obese children. After the weight loss program, a decrease in oxLDL levels was found in HR subjects and the oxLDL levels were associated with BMI‐SDS and cholesterol levels.