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Osteoprotegerin as a marker of cardiovascular risk in children and adolescents with type 1 diabetes
Author(s) -
Fekih Ons,
Triki Hamdi,
Triki Sonia,
Neffati Fadoua,
Chouchane Slaheddine,
Guediche Mohamed Neji,
Najjar Mohamed Fadhel
Publication year - 2017
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12379
Subject(s) - medicine , osteoprotegerin , diabetes mellitus , type 2 diabetes , endocrinology , receptor , activator (genetics)
Background Elevated osteoprotegerin ( OPG ) levels have been reported in patients with diabetes complications. We investigated whether plasma OPG levels can be used as a marker of cardiovascular risk in children and adolescents with type 1 diabetes ( T1D ). Methods Plasma blood samples were obtained from 243 subjects (143 children and adolescents with T1D and 100 healthy controls). OPG concentrations were measured by enzyme‐linked immunosorbent assay ( ELISA ) method. All data were analyzed by using PASW statistics 18. Results A significant higher plasma OPG level was found in children with T1D compared to controls (p < 0.001). A significant increase of OPG levels has been related to the glucose level ≥ 7 mmol/L (2.44 [0.01–6.22] vs. 2.16 [0.13–6.22] pmol/L, p = 0.019), microalbuminuria ≥ 30 mg/24 h (3.71 [0.160–6.03] vs. 2.26 [0.01–6.22] pmol/L, p < 0.001), and cystatin‐C ≥ 0.789 mg/L (2.64 [0.37–6.22] vs. 2.11 [0.01–5.82] pmol/L, p < 0.001). We noted a significant higher frequency of children with increased cystatin‐C levels in the group with elevated plasma level of OPG compared with those with normal levels (49 vs. 18%, respectively) with an odds ratio ( OR ) = 4.42 [1.41–13.84] (p = 0.006). We showed a significant increase of OPG levels when the number of cardiovascular risk factors exceeds 3 (p = 0.001). Conclusion OPG may be a potential biomarker of cardiovascular risk in T1D . Implementation of OPG determination in the clinical laboratory setting would be useful in order to better stratify patients and to assess the most adequate treatment.