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Insulin resistance, role of metformin and other non‐insulin therapies in pediatric type 1 diabetes
Author(s) -
Bacha Fida,
Klinepeter Bartz Sara
Publication year - 2016
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12337
Subject(s) - medicine , metformin , glycemic , insulin resistance , insulin , diabetes mellitus , type 2 diabetes , type 1 diabetes , intensive care medicine , disease , endocrinology
Type 1 diabetes mellitus ( T1DM ) in youth is a challenging chronic medical condition. Its management should address not only the glycemic control but also insulin resistance and cardiovascular disease risk factors which are increasingly recognized to be present in youth with TID . Current knowledge on the mechanisms of insulin resistance in T1DM is reviewed. The use of adjunctive therapies that are beneficial to achieve adequate glycemic control while mitigating the effects of insulin resistance are discussed with a focus on metformin therapy and an overview of other new pharmacologic agents.