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Advanced glycation end products, measured in skin, vs. HbA1c in children with type 1 diabetes mellitus
Author(s) -
Banser Alena,
Naafs Jolanda C,
HoorwegNijman Jantine JG,
van de Garde Ewoudt MW,
van der Vorst Marja MJ
Publication year - 2016
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12311
Subject(s) - medicine , diabetes mellitus , type 2 diabetes mellitus , type 1 diabetes , anthropometry , endocrinology
Background and objective Advanced glycation end products ( AGEs ) are considered major contributors to microvascular and macrovascular complications in adult patients with diabetes mellitus. AGEs can be measured non‐invasively with skin autofluorescence ( sAF ). The primary aim was to determine sAF values in children with type 1 diabetes mellitus and to study correlations between sAF values and HbA1c and mean HbA1c over the year prior to measurement Research design and methods In children with type 1 diabetes mellitus, sAF values were measured using the AGE Reader®. Laboratory and anthropometric values were extracted from medical charts. Correlations were studied using Pearson's correlation coefficient. Multivariable linear regression analysis was conducted to evaluate the effect of multiple study parameters on sAF values. Results The mean sAF value was 1.33 ± 0.36 arbitrary units ( AU ) in children with type 1 diabetes mellitus (n = 144). sAF values correlated positively with HbA1c measured at the same time (r = 0.485; p < 0.001), mean HbA1c over the year prior to measurement (r = 0.578; p < 0.001), age (r = 0.337; p < 0.001), duration of type 1 diabetes mellitus (r = 0.277; p = 0.001), serum triglycerides (r = 0.399; p < 0.001), and total cholesterol (r = 0.352; p = 0.001). sAF values were significantly higher in patients with non‐white skin (1.56 vs. 1.27 AU , respectively, p = 0.001). Conclusions In children with type 1 diabetes, sAF values correlate strongly with single HbA1c and mean HbA1c , making the non‐invasive sAF measurement an interesting alternative to provide information about cumulative hyperglycemic states. To determine the value of sAF measurement in predicting long‐term microvascular and macrovascular complications, further prospective follow‐up studies are needed.