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Clinical implementation of islet transplantation: A current assessment
Author(s) -
Bottino Rita,
Trucco Massimo
Publication year - 2015
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12287
Subject(s) - medicine , immunosuppression , islet , transplantation , pancreas transplantation , type 1 diabetes , diabetes mellitus , islet cell transplantation , intensive care medicine , beta cell , pancreas , insulin , surgery , endocrinology , kidney transplantation
Beta‐cell replacement is the only physiologically relevant alternative to insulin injections in patients with type 1 diabetes (T1D). Pancreas and islet transplantation from deceased organ donors can provide a new beta‐cell pool to produce insulin, help blood glucose management, and delay secondary diabetes complications. For children and adolescents with T1D, whole pancreas transplantation is not a viable option because of surgical complications, whereas islet transplantation, even if it is procedurally simpler, must still overcome the burden of immunosuppression to become a routine therapy for children in the future.