Premium Clinical implementation of islet transplantation: A current assessment
Author(s)
Bottino Rita,
Trucco Massimo
Publication year2015
Publication title
pediatric diabetes
Resource typeJournals
Abstract Beta‐cell replacement is the only physiologically relevant alternative to insulin injections in patients with type 1 diabetes (T1D). Pancreas and islet transplantation from deceased organ donors can provide a new beta‐cell pool to produce insulin, help blood glucose management, and delay secondary diabetes complications. For children and adolescents with T1D, whole pancreas transplantation is not a viable option because of surgical complications, whereas islet transplantation, even if it is procedurally simpler, must still overcome the burden of immunosuppression to become a routine therapy for children in the future.
Subject(s)beta cell , diabetes mellitus , endocrinology , immunosuppression , insulin , intensive care medicine , islet , islet cell transplantation , kidney transplantation , medicine , pancreas , pancreas transplantation , surgery , transplantation , type 1 diabetes
Language(s)English
SCImago Journal Rank1.678
H-Index75
eISSN1399-5448
pISSN1399-543X
DOI10.1111/pedi.12287

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