Clinical implementation of islet transplantation: A current assessment | Zendy

Bottino Rita | Zendy; Trucco Massimo | Zendy

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Clinical implementation of islet transplantation: A current assessment

Author(s) -

Bottino Rita,

Trucco Massimo

Publication year - 2015

Publication title -

pediatric diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.678

H-Index - 75

eISSN - 1399-5448

pISSN - 1399-543X

DOI - 10.1111/pedi.12287

Subject(s) - medicine , immunosuppression , islet , transplantation , pancreas transplantation , type 1 diabetes , diabetes mellitus , islet cell transplantation , intensive care medicine , beta cell , pancreas , insulin , surgery , endocrinology , kidney transplantation

Beta‐cell replacement is the only physiologically relevant alternative to insulin injections in patients with type 1 diabetes (T1D). Pancreas and islet transplantation from deceased organ donors can provide a new beta‐cell pool to produce insulin, help blood glucose management, and delay secondary diabetes complications. For children and adolescents with T1D, whole pancreas transplantation is not a viable option because of surgical complications, whereas islet transplantation, even if it is procedurally simpler, must still overcome the burden of immunosuppression to become a routine therapy for children in the future.

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