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Lack of evidence for progression of atherosclerosis during puberty in type 1 diabetes
Author(s) -
Peña Alexia S.,
Maftei Oana,
Harrington Jennifer,
Anderson Jemma,
Hirte Craig,
Gent Roger,
Couper Jennifer
Publication year - 2016
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12265
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , type 1 diabetes , cohort , intima media thickness , prospective cohort study , cohort study , endocrinology , pediatrics , cardiology , carotid arteries
Objectives Children with type 1 diabetes have early changes in vascular structure with increased aortic intima–media thickness ( aIMT ) or carotid IMT ( cIMT ). aIMT may be an earlier, more sensitive marker; however, longitudinal data in type 1 diabetes are lacking. This study will aim to evaluate changes in vascular structure ( aIMT and cIMT ) over 2 yr during puberty in children with type 1 diabetes and compare them with those in healthy children. Research design and methods A total of 110 children (aged 10–18 yr, 55 males) participated in a prospective cohort study, including 77 children with type 1 diabetes and 33 age‐ and sex‐matched healthy children. Ultrasound assessments of aIMT and cIMT ; and clinical and biochemical data were collected at baseline and 2 yr later. Results Mean and maximal aIMT or cIMT did not worsen over time in children with type 1 diabetes compared with healthy children. Longer duration of diabetes related to an increase in aIMT . Improvement in HDL cholesterol and leptin related to a decrease in aIMT . Higher baseline IMT related to an improvement in IMT in children with type 1 diabetes (mean and maximal aIMT : β = −0.52, p < 0.001; β = −0.49, p = 0.001, and mean and maximal cIMT : β = −0.36, p = 0.003; β = −0.40, p = 0.001), independent of cardiovascular risk factors. Conclusions Aortic and carotid IMT does not deteriorate during puberty in children with type 1 diabetes. This has implications for the design of interventional studies in this important age group.