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The spectrum of clinical presentation, diagnosis, and management of mitochondrial forms of diabetes
Author(s) -
Karaa Amel,
Goldstein Amy
Publication year - 2015
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12223
Subject(s) - medicine , diabetes mellitus , presentation (obstetrics) , mitochondrial disease , pediatrics , mitochondrial dna , intensive care medicine , bioinformatics , endocrinology , genetics , surgery , biology , gene
Primary mitochondrial diseases refer to a group of heterogeneous and complex genetic disorders affecting 1:5000 people. The true prevalence is anticipated to be even higher because of the complexity of achieving a diagnosis in many patients who present with multisystemic complaints ranging from infancy to adulthood. Diabetes is a prominent feature of several of these disorders which might be overlooked by the endocrinologist. We here review mitochondrial disorders and describe the phenotypic and pathogenetic differences between mitochondrial diabetes mellitus ( mDM ) and other more common forms of diabetes mellitus.