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Association of serum uric acid levels to inflammation biomarkers and endothelial dysfunction in obese prepubertal children
Author(s) -
Valle Miguel,
Martos Rosario,
Cañete María Dolores,
Valle Rosario,
van Donkelaar Eva L,
Bermudo Francisco,
Cañete Ramón
Publication year - 2015
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12199
Subject(s) - medicine , uric acid , endothelial dysfunction , endocrinology , body mass index , insulin resistance , c reactive protein , metabolic syndrome , inflammation , obesity , lipid profile , endothelial activation , creatinine , cholesterol , systemic inflammation , insulin , blood pressure
Abstract Background High serum uric acid ( SUA ) levels are present in patients with metabolic syndrome ( MetS ), when the latter is associated with endothelial dysfunction, inflammation, and hypertension. This increase in SUA levels may have a key role in cardiovascular diseases. Objective We aim to quantify the differences in inflammation biomarkers, endothelial dysfunction, and parameters associated with MetS in obese prepubertal children compared to non‐obese children, and determine if there is a relationship between uric acid levels and these variables. Methods A cross‐sectional study was carried out on obese children (6–9 yr old). The study included 43 obese children and the same number of non‐obese children (control group), matched by age and sex. SUA , C‐reactive protein ( CRP ), interleukin‐6 ( IL ‐6), soluble intercellular adhesion molecule‐1 ( sICAM ‐1), glucose, insulin, lipid profile, and blood pressure were all measured. Results SUA levels, CRP , and sICAM ‐1 were significantly higher in obese children. In the obese group, SUA levels showed a positive correlation with body mass index ( BMI ), insulin, homeostasis model assessment for insulin resistance ( HOMA‐IR ), CRP , IL ‐6, sICAM ‐1, and triglycerides (TGs), and correlated negatively with high‐density lipoprotein cholesterol ( HDL ‐C) and Apo‐ AI , but not with Apo‐B. When adjusted for age, sex, and creatinine, it was noted that SUA levels are independent predictive factors for sICAM ‐1, CRP , and IL ‐6. Conclusions Inflammation biomarkers, endothelial dysfunction, and parameters associated with MetS are elevated in obese prepubertal children and correlate to uric acid levels.