Premium
Impaired endothelial function in adolescents with overweight or obesity measured by peripheral artery tonometry
Author(s) -
Pareyn Aagje,
Allegaert Karel,
Verhamme Peter,
Vinckx Joseph,
Casteels Kristina
Publication year - 2015
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12139
Subject(s) - overweight , medicine , obesity , body mass index , endothelial dysfunction , confounding , reactive hyperemia , diabetes mellitus , endocrinology , cardiology , vasodilation
Background Overweight and obesity in adolescents are associated with a subsequent increased mortality due to cardiovascular disease in adulthood. The reactive hyperemia‐peripheral artery tonometry ( RH‐PAT ) is a non‐invasive method for endothelial function assessment. Objective The goal of this study is to investigate endothelial function as assessed with the RH‐PAT in adolescents with overweight or obesity. Methods In 27 adolescents with overweight or obesity (16 males, 11 females) and 25 control subjects (12 males, 13 females) (age 12–20 yr) RH‐PAT score and baseline pulse amplitude were measured after an overnight fast. Confounding risk factors for endothelial dysfunction, including smoking and diabetes mellitus were excluded. Results RH‐PAT score was lower in adolescents with overweight or obesity compared to healthy controls, whereas their baseline pulse amplitude was higher (p = 0.027 and p < 0.0001, respectively). A significantly positive correlation was seen between baseline pulse amplitude and body mass index standard deviation score in the group with overweight or obese subjects. Conclusions Endothelial dysfunction, measured by lower RH‐PAT score and higher baseline pulse amplitude, was present in overweight adolescents. Interestingly, we also report for the first time in the literature a significant difference in baseline pulse amplitude between overweight adolescents compared to their peers.