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Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control
Author(s) -
Nguyen Thanh,
Obeid Joyce,
Walker Rachel G,
Krause Matthew P,
Hawke Thomas J,
McAssey Karen,
Vandermeulen John,
Timmons Brian W
Publication year - 2015
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12117
Subject(s) - medicine , glycemic , diabetes mellitus , type 1 diabetes , type 2 diabetes mellitus , physical fitness , physical therapy , physical activity , endocrinology
Background Patients with type 1 diabetes mellitus ( T1DM ) may experience poor muscle health as a result of chronic hyperglycemia. Despite this, muscle function in children with T1DM with good or poor glycemic control has yet to be examined in detail. Objective To assess differences in muscle‐related fitness variables in children with T1DM with good glycemic control ( T1DM‐G ), as well as those with poor glycemic control ( T1DM‐P ), and non‐diabetic, healthy controls. Subjects Eight children with T1DM‐G [glycosylated hemoglobin ( HbA1c ) ≤ 7.5% for 9 months], eight children with T1DM‐P ( HbA1c ≥ 9.0% for 9 months), and eight healthy controls completed one exercise session. Methods Anaerobic and aerobic muscle functions were assessed with a maximal isometric grip strength test, a Wingate test, and an incremental continuous cycling test until exhaustion. Blood samples were collected at rest to determine HbA1c at the time of testing. Physical activity was monitored over 7 d using accelerometry. Results Children with T1DM‐P displayed lower peak oxygen consumption ( VO 2peak ) values (mL/kg/min) compared to healthy controls ( T1DM‐P : 33.2 ± 5.6, controls: 43.5 ± 6.3, p < 0.01), while T1DM‐G (43.5 ± 6.3) had values similar to controls and T1DM‐P . There was a negative relationship between VO 2peak and HbA1c % (r = −0.54, p < 0.01). All groups were similar in all other fitness variables. There were no group differences in physical activity variables. Conclusion Children with T1DM‐G did not display signs of impaired muscle function, while children with T1DM‐P have signs of altered aerobic muscle capacity.