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Pediatric Diabetes Consortium Type 1 Diabetes New Onset (NeOn) Study: factors associated with HbA1c levels one year after diagnosis
Author(s) -
Redondo Maria J,
Connor Crystal G,
Ruedy Katrina J,
Beck Roy W,
Kollman Craig,
Wood Jamie R,
Buckingham Bruce,
Klingensmith Georgeanna J,
Silverstein Janet,
Tamborlane William V
Publication year - 2014
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12061
Subject(s) - medicine , diabetic ketoacidosis , type 1 diabetes , diabetes mellitus , body mass index , univariate analysis , type 2 diabetes , insulin , socioeconomic status , pediatrics , multivariate analysis , endocrinology , population , environmental health
Objective To identify determinants of hemoglobin A1c ( HbA1c ) levels 1 yr after the diagnosis of type 1 diabetes ( T1D ) in participants in the Pediatric Diabetes Consortium ( PDC ) T1D New Onset ( NeOn ) Study. Research design and methods: Diabetes‐specific as well as socioeconomic factors during the first year following diagnosis were analyzed in 857 participants (mean age 9.1 yrs, 51% female, 66% non‐Hispanic White) not participating in an intervention study who had an HbA1c value at 12 months. Result Mean ± SD HbA1c at 1 yr was 62 ± 16 mmol/mol (7.8% ± 1.5). In univariate and multivariate analyses, clinical center, non‐Hispanic White race, private health insurance, living with both parents, higher frequency of self‐monitoring of blood glucose ( SMBG ), and lower insulin requirements were associated with lower HbA1c concentrations at 1 yr (p < 0.01). No association was found with gender, age, Tanner stage, body mass index ( BMI ), diabetic ketoacidosis ( DKA ) at onset, number of positive autoantibodies or HbA1c at onset, or number of visits to diabetes physician during the first year. Conclusions White race, higher socioeconomic status, two‐parent household, more frequent SMBG , and low insulin requirements are associated with lower HbA1c concentration 1 yr after the onset of T1D in children.