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Evaluation of glycated hemoglobin and fetal hemoglobin‐adjusted HbA1c measurements in infants
Author(s) -
Suzuki Shigeru,
Koga Masafumi,
Niizeki Noriyasu,
Furuya Akiko,
Matsuo Kumihiro,
Tanahashi Yusuke,
Tsuchida Etsushi,
Nohara Fumikatsu,
Okamoto Toshio,
Nagaya Ken,
Azuma Hiroshi
Publication year - 2013
Publication title -
pediatric diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.678
H-Index - 75
eISSN - 1399-5448
pISSN - 1399-543X
DOI - 10.1111/pedi.12013
Subject(s) - medicine , glycated hemoglobin , fetal hemoglobin , hemoglobin , fetus , pregnancy , obstetrics , pediatrics , diabetes mellitus , endocrinology , type 2 diabetes , biology , genetics
Background As the presence of fetal hemoglobin ( HbF ) affects the accuracy of hemoglobin A1c ( HbA1c ) analysis methods, HbA1c measurement may not be a good indicator for patients with neonatal diabetes mellitus, whereas glycated albumin ( GA ) may be a good indicator. Objective To investigate whether total glycated hemoglobin ( GHb ) or HbF ‐adjusted HbA1c (adj‐ HbA1c ) can act as a glycemic control marker in infants. Subjects and Methods Plasma glucose ( PG ), GA , HbF , GHb measured using the affinity method, and HbA1c measured using the latex‐immunoturbidimetry ( LA ) or the high‐performance liquid chromatography ( HPLC ) methods were determined in 26 full‐term newborn infants aged 4–234 d. Adj‐ HbA1c was calculated as HbA1c /(total Hb − HbF ). Results GHb , adj‐ HbA1c measured using the LA and the HPLC methods were 4.8 ± 0.5%, 4.5 ± 0.5%, and 4.7 ± 0.6%, respectively. GA was most positively correlated with PG (r = 0.696, p < 0.0001). GHb was positively correlated with both PG (r = 0.479, p = 0.013) and GA (r = 0.727, p < 0.0001). Adj‐ HbA1c measured using the LA method was positively correlated with GA (r = 0.465, p = 0.017), but not PG (r = 0.304, p = 0.132). Adj‐ HbA1c measured using the HPLC method was correlated with neither PG (r = −0.077, p = 0.710) nor GA (r = 0.360, p = 0.071). Conclusions GHb measured using the affinity method may be a useful glycemic control marker in infants. Although adj‐ HbA1c measured using the LA method was correlated with GA , it may not be a practical measure because it was not correlated with PG and determining HbF levels using HPLC method can be troublesome. Adj‐ HbA1c measured using the HPLC method should not be used as a glycemic marker in infants.