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Dynamic thiol/disulphide homeostasis and pathogenesis of Kawasaki disease
Author(s) -
Kaman Ayşe,
Aydın Teke Türkan,
Gayretli Aydın Zeynep Gökçe,
Karacan Küçükali Gülin,
Neşelioğlu Salim,
Erel Özcan,
Tanır Gönül
Publication year - 2019
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13958
Subject(s) - thiol , homeostasis , medicine , kawasaki disease , pathogenesis , endocrinology , biochemistry , chemistry , artery
Background Kawasaki disease (KD) is an acute, self‐limited, systemic vasculitis of unknown etiology. In the present study, we investigated whether there is a relationship between KD and dynamic thiol/disulphide homeostasis. Methods This case–control study involved KD patients and healthy controls. Plasma total, native and disulphide thiol and the disulphide/native, disulphide/total and native thiol/total thiol ratios of all patients and the control group were analyzed simultaneously. Results A total of 20 patients with KD (male/female, 12/8) and 25 age‐ and gender‐matched healthy controls (male/female, 12/13) were evaluated. Native, total thiol and native thiol/total thiol ratio were significantly lower in KD patients than in the control group ( P < 0.001). In contrast, disulphide thiol, disulphide/native thiol and disulphide/total thiol ratios were significantly higher in KD patients than control subjects ( P < 0.001). In KD patients with coronary artery lesion (CAL), the native thiol and total thiol were significantly lower than in KD patients without CAL. In KD patients with CAL, the ratios of disulphide/total thiol and disulphide/native thiol were significantly higher than in those without CAL ( P = 0.02 and P = 0.02, respectively), whereas the ratio of native/total thiol was significantly lower ( P = 0.02). Conclusion The KD patients had lower plasma thiol (native and total) and higher disulphide thiol than controls, indicating that dynamic thiol/disulphide homeostasis might be an important indicator of inflammation in KD. Alteration and shifting of thiol/disulphide homeostasis to the oxidized side are correlated with the pathogenesis of KD and CAL.