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Urinary angiotensinogen in pediatric urinary tract infection
Author(s) -
Mayumi Reina,
Murano Yayoi,
Yokota Reina,
Nakao Akihiro,
Miyazaki Nao,
Hara Taichi,
Mizutani Akira,
Hayashi Kuniyoshi,
Sakurai Yumiko,
Shoji Hiromichi,
Nakazawa Tomoyuki,
Shimizu Toshiaki
Publication year - 2019
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/ped.13890
Subject(s) - medicine , urinary system , urology
Background Urinary tract infection ( UTI ) is one of the most common diseases in children, and urinary angiotensinogen (U‐ AGT ) is a new biomarker gathering attention in many renal diseases. U‐ AGT reflects intrarenal renin–angiotensin system ( RAS ) activity. We conducted a study to measure U‐ AGT in children <4 months old with UTI . Methods All children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included. Patients were divided into a UTI group and a non‐ UTI group, and U‐ AGT was measured. Results Median U‐AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/ dL , range, 0.025–2.753 ng/ dL vs 0.13 ng/ dL , range, 0.008–1.697 ng/ dL , respectively; P < 0.05). Conclusions U‐AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI .